Hématologie

Bendamustin medac

Description du produit

The cytostatic drug bendamustine is a nitrogen-lost derivative from the series of alkylating substances. The substance alkylates RNA, DNA and proteins and renders them useless for cell metabolism. Multiple DNA cross-linkings (cross-linking) and cleavage of DNA chains occur. This impedes replication and cell division. Bendamustine has a non-specific effect on cell cycle phases.

Dénomination Commune Internationale (DCI)

Bendamustine hydrochloride monohydrate

Mode d'action

Bendamustin medac is an alkylating substance containing the active substance bendamustine hydrochloride. The alkalising effect of bendamustine hydrochloride is essentially based on the cross-linking of DNA single and double strands, which impairs the synthesis and repair of DNA.

Indication

  • Chronic lymphocytic leukaemia (Binet stage B or C)
  • Indolent non-Hodgkin’s lymphoma
  • Multiple myeloma (Durie-Salmon stage II with progress or stage III)

Dosage

Powder for concentrate for solution for infusion:

  • 25 mg (10 ml)
  • 100 mg (40 ml)

Not all pack sizes may be marketed.

Matériaux

Abbreviated product information

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Summary of Product Characteristics

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Patient Information Leaflet

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