Description du produit

Bleomycin is a chemotherapy agent used to treat various malignancies, including head and neck malignancy, lymphoma, and testicular tumors, among others. Bleomycin is a glycopeptide antibiotic with a unique mechanism of antitumor activity. It is well-known to cause s breaks in cellular DNA leading finally to instability of damaged tumor cells. Due to its complicated structure, the production of Bleomycin mainly relies on the microbial fermentation of Streptomyces verticillus.

Dénomination Commune Internationale (DCI)

Bleomycin sulphate

Mode d'action

Bleomycin has a cytostatic effect because of its specific binding to DNA, where it causes strand breaks.

After administration, bleomycin forms an active complex with copper (Cu2+) and thus passes through the cell membrane into the cell interior. When the copper splits off in the cell plasma, bleomycin binds to DNA in the nucleus. Activated by free oxygen radicals, it induces strand breaks in the DNA. The greatest susceptibility is shown in cells in the G2 and M phases of the cell cycle.


  • Squamous cell carcinoma (SCC) of the head and neck, external genitalia and cervix
  • Hodgkin’s lymphoma
  • Non-Hodgkin’s lymphoma of intermediate and high malignancy in adults
  • Testis carcinoma (seminoma and non-seminoma)
  • Intrapleural therapy of malignant pleural effusion


Powder for solution for injection:

  • 15000 IU (Ph. Eur.) / 10ml

Not all pack sizes may be marketed.


Abbreviated product information

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