Oncologie
Bleomycin is a chemotherapy agent used to treat various malignancies, including head and neck malignancy, lymphoma, and testicular tumors, among others. Bleomycin is a glycopeptide antibiotic with a unique mechanism of antitumor activity. It is well-known to cause s breaks in cellular DNA leading finally to instability of damaged tumor cells. Due to its complicated structure, the production of Bleomycin mainly relies on the microbial fermentation of Streptomyces verticillus.
Bleomycin sulphate
Bleomycin has a cytostatic effect because of its specific binding to DNA, where it causes strand breaks.
After administration, bleomycin forms an active complex with copper (Cu2+) and thus passes through the cell membrane into the cell interior. When the copper splits off in the cell plasma, bleomycin binds to DNA in the nucleus. Activated by free oxygen radicals, it induces strand breaks in the DNA. The greatest susceptibility is shown in cells in the G2 and M phases of the cell cycle.
Powder for solution for injection:
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